Primary Isoniazid Prophylaxis against Tuberculosis in HIV-Exposed Children | Zendy

Shabir A. Madhi | Zendy; Sharon Nachman | Zendy; Avy Violari | Zendy; Soyeon Kim | Zendy; Mark F. Cotton | Zendy; Raziya Bobat | Zendy; Patrick JeanPhilippe | Zendy; George McSherry | Zendy; Charles D. Mitchell | Zendy

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Primary Isoniazid Prophylaxis against Tuberculosis in HIV-Exposed Children

Author(s) -

Shabir A. Madhi,

Sharon Nachman,

Avy Violari,

Soyeon Kim,

Mark F. Cotton,

Raziya Bobat,

Patrick JeanPhilippe,

George McSherry,

Charles D. Mitchell

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1011214

Subject(s) - medicine , isoniazid , tuberculosis , chemoprophylaxis , human immunodeficiency virus (hiv) , pediatrics , placebo , randomized controlled trial , virology , immunology , pathology , alternative medicine

The dual epidemic of human immunodeficiency virus (HIV) and tuberculosis is a major cause of sickness and death in sub-Saharan Africa. We conducted a double-blind, randomized, placebo-controlled trial of preexposure isoniazid prophylaxis against tuberculosis in HIV-infected children and uninfected children exposed to HIV during the perinatal period.

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