Genetic Basis for In Vivo Daptomycin Resistance in Enterococci | Zendy

César A. Arias | Zendy; Diana Panesso | Zendy; Danielle M. McGrath | Zendy; Xiang Qin | Zendy; María F. Mojica | Zendy; Corwin Miller | Zendy; Lorena Díaz | Zendy; Truc T. Tran | Zendy; Sandra Rincón | Zendy; E. Magda Barbu | Zendy; Jinnethe Reyes | Zendy; Jung Hyeob Roh | Zendy; Elizabeth A. Lobos | Zendy; Erica Sodergren | Zendy; Renata Pasqualini | Zendy; Wadih Arap | Zendy; John P. Quinn | Zendy; Yousif Shamoo | Zendy; Barbara E. Murray | Zendy; George M. Weinstock | Zendy

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Genetic Basis for In Vivo Daptomycin Resistance in Enterococci

Author(s) -

César A. Arias,

Diana Panesso,

Danielle M. McGrath,

Xiang Qin,

María F. Mojica,

Corwin Miller,

Lorena Díaz,

Truc T. Tran,

Sandra Rincón,

E. Magda Barbu,

Jinnethe Reyes,

Jung Hyeob Roh,

Elizabeth A. Lobos,

Erica Sodergren,

Renata Pasqualini,

Wadih Arap,

John P. Quinn,

Yousif Shamoo,

Barbara E. Murray,

George M. Weinstock

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1011138

Subject(s) - daptomycin , enterococcus faecalis , microbiology and biotechnology , lipopeptide , biology , enterococcus , allele , antibiotics , vancomycin , gene , staphylococcus aureus , genetics , bacteria

Daptomycin is a lipopeptide with bactericidal activity that acts on the cell membrane of enterococci and is often used off-label to treat patients infected with vancomycin-resistant enterococci. However, the emergence of resistance to daptomycin during therapy threatens its usefulness.

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