Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection
Author(s) -
Bruce R. Bacon,
Stuart C. Gordon,
Eric Lawitz,
Patrick Marcellin,
John M. Vierling,
Stefan Zeuzem,
Fred Poordad,
Zachary Goodman,
Heather L. Sings,
Navdeep Boparai,
Margaret Burroughs,
Clifford A. Brass,
Janice K. Albrecht,
Rafael Esteban
Publication year - 2011
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa1009482
Subject(s) - boceprevir , medicine , ribavirin , virology , hepatitis c virus , genotype , ns3 , telaprevir , chronic hepatitis , protease inhibitor (pharmacology) , virus , protease , immunology , viral load , gene , biology , enzyme , antiretroviral therapy , biochemistry
In patients with chronic infection with hepatitis C virus (HCV) genotype 1 who do not have a sustained response to therapy with peginterferon-ribavirin, outcomes after retreatment are suboptimal. Boceprevir, a protease inhibitor that binds to the HCV nonstructural 3 (NS3) active site, has been suggested as an additional treatment.
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