Protective Effect of Natural Rotavirus Infection in an Indian Birth Cohort | Zendy

Beryl Primrose Gladstone | Zendy; Sasirekha Ramani | Zendy; Indrani Mukhopadhya | Zendy; Jayaprakash Muliyil | Zendy; Rajiv Sarkar | Zendy; Andrea M. Rehman | Zendy; Shabbar Jaffar | Zendy; Miren IturrizaGómara | Zendy; James J. Gray | Zendy; David Brown | Zendy; Ulrich Desselberger | Zendy; Sue E. Crawford | Zendy; Jacob John | Zendy; Sudhir Babji | Zendy; Mary K. Estes | Zendy; Gagandeep Kang | Zendy

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Protective Effect of Natural Rotavirus Infection in an Indian Birth Cohort

Author(s) -

Beryl Primrose Gladstone,

Sasirekha Ramani,

Indrani Mukhopadhya,

Jayaprakash Muliyil,

Rajiv Sarkar,

Andrea M. Rehman,

Shabbar Jaffar,

Miren IturrizaGómara,

James J. Gray,

David Brown,

Ulrich Desselberger,

Sue E. Crawford,

Jacob John,

Sudhir Babji,

Mary K. Estes,

Gagandeep Kang

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1006261

Subject(s) - medicine , rotavirus , cohort , cohort study , rotavirus infections , diarrhea , pediatrics , virology , immunology

More than 500,000 deaths are attributed to rotavirus gastroenteritis annually worldwide, with the highest mortality in India. Two successive, naturally occurring rotavirus infections have been shown to confer complete protection against moderate or severe gastroenteritis during subsequent infections in a birth cohort in Mexico. We studied the protective effect of rotavirus infection on subsequent infection and disease in a birth cohort in India (where the efficacy of oral vaccines in general has been lower than expected).

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