Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease | Zendy

Gerd Walz | Zendy; Klemens Budde | Zendy; Marwan Mannaa | Zendy; Jens Nürnberger | Zendy; Christoph Wanner | Zendy; Claudia Sommerer | Zendy; Ulrich Kunzendorf | Zendy; Bernhard Banas | Zendy; Walter H. Hörl | Zendy; Nicholas Obermüller | Zendy; Wolfgang Arns | Zendy; Hermann Pavenstädt | Zendy; Jens Gaedeke | Zendy; Martin Büchert | Zendy; Christoph May | Zendy; Harald Gschaidmeier | Zendy; Stefan Krämer | Zendy; KaiUwe Eckardt | Zendy

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Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

Author(s) -

Gerd Walz,

Klemens Budde,

Marwan Mannaa,

Jens Nürnberger,

Christoph Wanner,

Claudia Sommerer,

Ulrich Kunzendorf,

Bernhard Banas,

Walter H. Hörl,

Nicholas Obermüller,

Wolfgang Arns,

Hermann Pavenstädt,

Jens Gaedeke,

Martin Büchert,

Christoph May,

Harald Gschaidmeier,

Stefan Krämer,

KaiUwe Eckardt

Publication year - 2010

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1003491

Subject(s) - medicine , autosomal dominant polycystic kidney disease , everolimus , polycystic kidney disease , cyst , disease , pi3k/akt/mtor pathway , discovery and development of mtor inhibitors , renal replacement therapy , kidney , pathology , bioinformatics , genetics , biology , signal transduction

Autosomal dominant polycystic kidney disease (ADPKD) is a slowly progressive hereditary disorder that usually leads to end-stage renal disease. Although the underlying gene mutations were identified several years ago, efficacious therapy to curtail cyst growth and prevent renal failure is not available. Experimental and observational studies suggest that the mammalian target of rapamycin (mTOR) pathway plays a critical role in cyst growth.

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