Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy | Zendy

Carolyn Y. Ho | Zendy; Begoña López | Zendy; Otávio R. CoelhoFilho | Zendy; Neal K. Lakdawala | Zendy; Allison L. Cirino | Zendy; Petr Jarolı́m | Zendy; Raymond Y. Kwong | Zendy; Arantxa González | Zendy; Steven D. Colan | Zendy; Jonathan G. Seidman | Zendy; Javier Dı́ez | Zendy; Christine E. Seidman | Zendy

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Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

Author(s) -

Carolyn Y. Ho,

Begoña López,

Otávio R. CoelhoFilho,

Neal K. Lakdawala,

Allison L. Cirino,

Petr Jarolı́m,

Raymond Y. Kwong,

Arantxa González,

Steven D. Colan,

Jonathan G. Seidman,

Javier Dı́ez,

Christine E. Seidman

Publication year - 2010

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa1002659

Subject(s) - hypertrophic cardiomyopathy , medicine , myocardial fibrosis , muscle hypertrophy , cardiology , fibrosis , left ventricular hypertrophy , cardiomyopathy , heart failure , sarcomere , endocrinology , myocyte , blood pressure

Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy and a proposed substrate for arrhythmias and heart failure. In animal models, profibrotic genetic pathways are activated early, before hypertrophic remodeling. Data showing early profibrotic responses to sarcomere-gene mutations in patients with hypertrophic cardiomyopathy are lacking.

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