Genomewide Association betweenGLCCI1and Response to Glucocorticoid Therapy in Asthma | Zendy

Kelan G. Tantisira | Zendy; Jessica LaskySu | Zendy; Michishige Harada | Zendy; Amy Murphy | Zendy; Augusto A. Litonjua | Zendy; Blanca E. Himes | Zendy; Christoph Lange | Zendy; Ross Lazarus | Zendy; Jody Sylvia | Zendy; Barbara J. Klanderman | Zendy; Qing Duan | Zendy; Weiliang Qiu | Zendy; Tomomitsu Hirota | Zendy; Fernando D. Martínez | Zendy; David Mauger | Zendy; Christine A. Sorkness | Zendy; Stanley J. Szefler | Zendy; Stephen C. Lazarus | Zendy; Robert F. Lemanske | Zendy; Stephen P. Peters | Zendy; John J. Lima | Zendy; Yusuke Nakamura | Zendy; Mayumi Tamari | Zendy; Scott T. Weiss | Zendy

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Genomewide Association betweenGLCCI1and Response to Glucocorticoid Therapy in Asthma

Author(s) -

Kelan G. Tantisira,

Jessica LaskySu,

Michishige Harada,

Amy Murphy,

Augusto A. Litonjua,

Blanca E. Himes,

Christoph Lange,

Ross Lazarus,

Jody Sylvia,

Barbara J. Klanderman,

Qing Duan,

Weiliang Qiu,

Tomomitsu Hirota,

Fernando D. Martínez,

David Mauger,

Christine A. Sorkness,

Stanley J. Szefler,

Stephen C. Lazarus,

Robert F. Lemanske,

Stephen P. Peters,

John J. Lima,

Yusuke Nakamura,

Mayumi Tamari,

Scott T. Weiss

Publication year - 2011

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0911353

Subject(s) - medicine , asthma , glucocorticoid , pharmacogenetics , inhaled corticosteroids , drug response , genome wide association study , association (psychology) , oncology , bioinformatics , genotype , genetics , pharmacology , single nucleotide polymorphism , gene , drug , biology , psychotherapist , psychology

The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids.

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