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Rapid Molecular Detection of Tuberculosis and Rifampin Resistance
Author(s) -
Catharina Boehme,
Pamela Nabeta,
Doris Hillemann,
Mark P. Nicol,
Shubhada Shenai,
Fiorella Krapp,
Jenny Allen,
Rasim Tahirli,
Robert Blakemore,
Roxana Rustomjee,
Ana Milovic,
Martin Jones,
Sean M. O’Brien,
David H. Persing,
Sabine Ruesch-Gerdes,
Eduardo Gotuzzo,
Camilla Rodrigues,
David Alland,
Mark D. Perkins
Publication year - 2010
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa0907847
Subject(s) - tuberculosis , mycobacterium tuberculosis , medicine , sputum , drug resistance , microbiology and biotechnology , virology , rifampicin , tuberculosis diagnosis , biology , pathology
Global control of tuberculosis is hampered by slow, insensitive diagnostic methods, particularly for the detection of drug-resistant forms and in patients with human immunodeficiency virus infection. Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect.

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