A Large-Scale, Consortium-Based Genomewide Association Study of Asthma | Zendy

Miriam F. Moffatt | Zendy; Marta Gut | Zendy; Florence Démenais | Zendy; David P. Strachan | Zendy; Emmanuelle Bouzigon | Zendy; Simon Heath | Zendy; Erika von Mutius | Zendy; Martin Farrall | Zendy; Mark Lathrop | Zendy; William Cookson | Zendy

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A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

Author(s) -

Miriam F. Moffatt,

Marta Gut,

Florence Démenais,

David P. Strachan,

Emmanuelle Bouzigon,

Simon Heath,

Erika von Mutius,

Martin Farrall,

Mark Lathrop,

William Cookson

Publication year - 2010

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0906312

Subject(s) - asthma , genotyping , medicine , single nucleotide polymorphism , genome wide association study , locus (genetics) , allele , genetic association , genetics , immunology , population , disease , genotype , gene , biology , environmental health

Susceptibility to asthma is influenced by genes and environment; implicated genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in identifying subtypes of asthma and determining whether intermediate phenotypes, such as elevation of the total serum IgE level, are causally linked to disease.

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