Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease | Zendy

Matthew M. Hsieh | Zendy; Elizabeth M. Kang | Zendy; Courtney D. Fitzhugh | Zendy; Mary Link | Zendy; Charles D. Bolan | Zendy; Roger Kurlander | Zendy; Richard W. Childs | Zendy; Griffin P. Rodgers | Zendy; Jonathan D. Powell | Zendy; John F. Tisdale | Zendy

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Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease

Author(s) -

Matthew M. Hsieh,

Elizabeth M. Kang,

Courtney D. Fitzhugh,

Mary Link,

Charles D. Bolan,

Roger Kurlander,

Richard W. Childs,

Griffin P. Rodgers,

Jonathan D. Powell,

John F. Tisdale

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0904971

Subject(s) - medicine , hematopoietic stem cell transplantation , transplantation , disease , stem cell , graft versus host disease , haematopoiesis , immunology , hematopoietic cell , cell , savior sibling , biology , genetics

Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection and graft-versus-host disease (GVHD) are additional barriers to its success. We performed nonmyeloablative stem-cell transplantation in adults with sickle cell disease.

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