Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2 | Zendy

Connie Celum | Zendy; Anna Wald | Zendy; Jairam R. Lingappa | Zendy; Amalia Magaret | Zendy; R.S. Wang | Zendy; Nelly Mugo | Zendy; Andrew Mujugira | Zendy; Jared M. Baeten | Zendy; James I. Mullins | Zendy; James P. Hughes | Zendy; Elizabeth A. Bukusi | Zendy; Craig R. Cohen | Zendy; Elly Katabira | Zendy; Allan Ronald | Zendy; James Kiarie | Zendy; Carey Farquhar | Zendy; Grace John Stewart | Zendy; Joseph Makhema | Zendy; Max Essex | Zendy; Edwin Were | Zendy; K H Fife | Zendy; Guy de Bruyn | Zendy; Glenda Gray | Zendy; James McIntyre | Zendy; Rachel Magi | Zendy; Saidi Kapiga | Zendy; David Coetzee | Zendy; Susan Allen | Zendy; Mubiana Inambao | Zendy; Kayitesi Kayitenkore | Zendy; Etienne Karita | Zendy; William Kanweka | Zendy; Sinéad Delany | Zendy; Helen Rees | Zendy; Bellington Vwalika | Zendy; Wendy Stevens | Zendy; Mical S. Campbell | Zendy; Katherine K. Thomas | Zendy; Robert W. Coombs | Zendy; Rhoda Ashley Morrow | Zendy; William L. H. Whittington | Zendy; M. Juliana McElrath | Zendy; Linda Barnes | Zendy; Renée Ridzon | Zendy; Lawrence Corey | Zendy

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Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2

Author(s) -

Connie Celum,

Anna Wald,

Jairam R. Lingappa,

Amalia Magaret,

R.S. Wang,

Nelly Mugo,

Andrew Mujugira,

Jared M. Baeten,

James I. Mullins,

James P. Hughes,

Elizabeth A. Bukusi,

Craig R. Cohen,

Elly Katabira,

Allan Ronald,

James Kiarie,

Carey Farquhar,

Grace John Stewart,

Joseph Makhema,

Max Essex,

Edwin Were,

K H Fife,

Guy de Bruyn,

Glenda Gray,

James McIntyre,

Rachel Magi,

Saidi Kapiga,

David Coetzee,

Susan Allen,

Mubiana Inambao,

Kayitesi Kayitenkore,

Etienne Karita,

William Kanweka,

Sinéad Delany,

Helen Rees,

Bellington Vwalika,

Wendy Stevens,

Mical S. Campbell,

Katherine K. Thomas,

Robert W. Coombs,

Rhoda Ashley Morrow,

William L. H. Whittington,

M. Juliana McElrath,

Linda Barnes,

Renée Ridzon,

Lawrence Corey

Publication year - 2010

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0904849

Subject(s) - herpes simplex virus , hsl and hsv , medicine , virology , transmission (telecommunications) , human immunodeficiency virus (hiv) , genital herpes , virus , herpes genitalis , sex organ , immunology , biology , electrical engineering , engineering , genetics

Most persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1.

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