Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee | Zendy

Nancy E. Lane | Zendy; Thomas J. Schnitzer | Zendy; C. Birbara | Zendy; Masoud Mokhtarani | Zendy; David L. Shelton | Zendy; Mike D. Smith | Zendy; M. Brown | Zendy

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Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

Author(s) -

Nancy E. Lane,

Thomas J. Schnitzer,

C. Birbara,

Masoud Mokhtarani,

David L. Shelton,

Mike D. Smith,

M. Brown

Publication year - 2010

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0901510

Subject(s) - osteoarthritis , medicine , nerve growth factor , analgesic , monoclonal antibody , knee pain , analgesic agents , bioinformatics , antibody , pharmacology , immunology , pathology , alternative medicine , receptor , biology

Increased expression of nerve growth factor in injured or inflamed tissue is associated with increased pain. This proof-of-concept study was designed to investigate the safety and analgesic efficacy of tanezumab, a humanized monoclonal antibody that binds and inhibits nerve growth factor.

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