A Randomized Trial of Doxycycline forMansonella perstansInfection | Zendy

Yaya Ibrahim Coulibaly | Zendy; Benoit Dembélé | Zendy; Abdallah A. Diallo | Zendy; Ettie M. Lipner | Zendy; Salif Seriba Doumbia | Zendy; Siaka Yamoussa Coulibaly | Zendy; Siaka Konaté | Zendy; Dapa A. Diallo | Zendy; Daniel Yalcouyé | Zendy; Joseph Kubofcik | Zendy; Ogobara K. Doumbo | Zendy; Abdel Kader Traoré | Zendy; Adama Diaman Kéita | Zendy; Michael P. Fay | Zendy; Sékou F. Traorè | Zendy; Thomas B. Nutman | Zendy; Amy D. Klion | Zendy

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A Randomized Trial of Doxycycline forMansonella perstansInfection

Author(s) -

Yaya Ibrahim Coulibaly,

Benoit Dembélé,

Abdallah A. Diallo,

Ettie M. Lipner,

Salif Seriba Doumbia,

Siaka Yamoussa Coulibaly,

Siaka Konaté,

Dapa A. Diallo,

Daniel Yalcouyé,

Joseph Kubofcik,

Ogobara K. Doumbo,

Abdel Kader Traoré,

Adama Diaman Kéita,

Michael P. Fay,

Sékou F. Traorè,

Thomas B. Nutman,

Amy D. Klion

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0900863

Subject(s) - doxycycline , medicine , wuchereria bancrofti , ivermectin , lymphatic filariasis , artemether , albendazole , gastroenterology , filariasis , immunology , surgery , antibiotics , veterinary medicine , biology , helminths , artemisinin , malaria , microbiology and biotechnology , plasmodium falciparum

Mansonella perstans infection is common in areas of Africa where Wuchereria bancrofti, a causative agent of lymphatic filariasis, is endemic. M. perstans is refractory to standard antifilarial therapies. The recent discovery of bacterial endosymbionts (e.g., wolbachia) in most filarial species, including M. perstans, provides new therapeutic options for reducing microfilaremia.

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