Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect | Zendy

Richard J. Caselli | Zendy; Amylou C. Dueck | Zendy; David Osborne | Zendy; Marwan N. Sabbagh | Zendy; Donald J. Connor | Zendy; Geoffrey L. Ahern | Zendy; Leslie C. Baxter | Zendy; Steven Z. Rapcsak | Zendy; Jiong Shi | Zendy; Bryan K. Woodruff | Zendy; Dona E.C. Locke | Zendy; Charlene HoffmanSnyder | Zendy; Gene E. Alexander | Zendy; Rosa Rademakers | Zendy; Eric M. Reiman | Zendy

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Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

Author(s) -

Richard J. Caselli,

Amylou C. Dueck,

David Osborne,

Marwan N. Sabbagh,

Donald J. Connor,

Geoffrey L. Ahern,

Leslie C. Baxter,

Steven Z. Rapcsak,

Jiong Shi,

Bryan K. Woodruff,

Dona E.C. Locke,

Charlene HoffmanSnyder,

Gene E. Alexander,

Rosa Rademakers,

Eric M. Reiman

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0809437

Subject(s) - apolipoprotein e , allele , medicine , cognitive decline , dementia , longitudinal study , neuropsychology , age of onset , endocrinology , psychology , cognition , disease , psychiatry , genetics , pathology , biology , gene

The APOE epsilon4 allele is associated with the risk of late-onset Alzheimer's disease. The age at which memory decline diverges among persons who are homozygous for the APOE epsilon4 allele, those who are heterozygous for the allele, and noncarriers is unknown.

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