Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data | Zendy

Teri E. Klein | Zendy; Altman Rb | Zendy; Niclas Eriksson | Zendy; Gage Bf | Zendy; Kimmel Se | Zendy; Lee Mt | Zendy; Limdi Na | Zendy; David Page | Zendy; Roden Dm | Zendy; Wagner Mj | Zendy; Michael D. Caldwell | Zendy; JA Johnson | Zendy

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Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

Author(s) -

Teri E. Klein,

Altman Rb,

Niclas Eriksson,

Gage Bf,

Kimmel Se,

Lee Mt,

Limdi Na,

David Page,

Roden Dm,

Wagner Mj,

Michael D. Caldwell,

JA Johnson

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0809329

Subject(s) - warfarin , medicine , pharmacogenetics , population , cohort , atrial fibrillation , genotype , biochemistry , chemistry , environmental health , gene

Genetic variability among patients plays an important role in determining the dose of warfarin that should be used when oral anticoagulation is initiated, but practical methods of using genetic information have not been evaluated in a diverse and large population. We developed and used an algorithm for estimating the appropriate warfarin dose that is based on both clinical and genetic data from a broad population base.

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