Denosumab in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer
Author(s) -
Matthew Smith,
Blair Egerdie,
Narciso Hernández Toriz,
Robert Feldman,
Teuvo L.J. Tammela,
Fred Saad,
Jiří Heráček,
Maciej Szwedowski,
Chunlei Ke,
Amy Kupic,
Benjamin Z. Leder,
Carsten Goessl
Publication year - 2009
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa0809003
Subject(s) - medicine , denosumab , bone mineral , femoral neck , androgen deprivation therapy , prostate cancer , urology , placebo , osteoporosis , bone density , surgery , cancer , pathology , alternative medicine
Androgen-deprivation therapy is well-established for treating prostate cancer but is associated with bone loss and an increased risk of fracture. We investigated the effects of denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor-kappaB ligand, on bone mineral density and fractures in men receiving androgen-deprivation therapy for nonmetastatic prostate cancer.
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