Functional Brown Adipose Tissue in Healthy Adults | Zendy

Kirsi A. Virtanen | Zendy; Martin E. Lidell | Zendy; Janne Orava | Zendy; Mikael Heglind | Zendy; Rickard Westergren | Zendy; Tarja Niemi | Zendy; Markku Taittonen | Zendy; Jukka Laine | Zendy; N. Savisto | Zendy; Sven Enerbäck | Zendy; Pirjo Nuutila | Zendy

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Functional Brown Adipose Tissue in Healthy Adults

Author(s) -

Kirsi A. Virtanen,

Martin E. Lidell,

Janne Orava,

Mikael Heglind,

Rickard Westergren,

Tarja Niemi,

Markku Taittonen,

Jukka Laine,

N. Savisto,

Sven Enerbäck,

Pirjo Nuutila

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0808949

Subject(s) - adipose tissue , brown adipose tissue , medicine , adipocyte , messenger rna , biopsy , endocrinology , pathology , biology , biochemistry , gene

Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.

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