Cold-Activated Brown Adipose Tissue in Healthy Men | Zendy

Wouter D. van Marken Lichtenbelt | Zendy; Joost W. Vanhommerig | Zendy; Nanda M. Smulders | Zendy; Jamie M.A.F.L. Drossaerts | Zendy; Gerrit J. Kemerink | Zendy; Nicole D. Bouvy | Zendy; Patrick Schrauwen | Zendy; G. J. J. Teule | Zendy

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Cold-Activated Brown Adipose Tissue in Healthy Men

Author(s) -

Wouter D. van Marken Lichtenbelt,

Joost W. Vanhommerig,

Nanda M. Smulders,

Jamie M.A.F.L. Drossaerts,

Gerrit J. Kemerink,

Nicole D. Bouvy,

Patrick Schrauwen,

G. J. J. Teule

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0808718

Subject(s) - brown adipose tissue , adipose tissue , overweight , medicine , thermogenesis , endocrinology , lean body mass , obesity , body mass index , weight loss , white adipose tissue , basal metabolic rate , physiology , body weight

Studies in animals indicate that brown adipose tissue is important in the regulation of body weight, and it is possible that individual variation in adaptive thermogenesis can be attributed to variations in the amount or activity of brown adipose tissue. Until recently, the presence of brown adipose tissue was thought to be relevant only in small mammals and infants, with negligible physiologic relevance in adult humans. We performed a systematic examination of the presence, distribution, and activity of brown adipose tissue in lean and obese men during exposure to cold temperature. Brown-adipose-tissue activity was studied in relation to body composition and energy metabolism.

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