IDH1andIDH2Mutations in Gliomas | Zendy

Hai Yan | Zendy; D. Williams Parsons | Zendy; Genglin Jin | Zendy; Roger E. McLendon | Zendy; B. Ahmed Rasheed | Zendy; Weishi Yuan | Zendy; Ivan Kos | Zendy; Ines Batinic̈Haberle | Zendy; Siân Jones | Zendy; Gregory J. Riggins | Zendy; Henry S. Friedman | Zendy; Allan H. Friedman | Zendy; David A. Reardon | Zendy; James E. Herndon | Zendy; Kenneth W. Kinzler | Zendy; Victor E. Velculescu | Zendy; Bert Vogelstein | Zendy; Darell D. Bigner | Zendy

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IDH1andIDH2Mutations in Gliomas

Author(s) -

Hai Yan,

D. Williams Parsons,

Genglin Jin,

Roger E. McLendon,

B. Ahmed Rasheed,

Weishi Yuan,

Ivan Kos,

Ines Batinic̈Haberle,

Siân Jones,

Gregory J. Riggins,

Henry S. Friedman,

Allan H. Friedman,

David A. Reardon,

James E. Herndon,

Kenneth W. Kinzler,

Victor E. Velculescu,

Bert Vogelstein,

Darell D. Bigner

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0808710

Subject(s) - idh2 , idh1 , isocitrate dehydrogenase , glioma , gene , mutation , somatic cell , cancer research , mutant , biology , genetics , enzyme , biochemistry

A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas).

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