The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis | Zendy

Andreas H. Diacon | Zendy; Alexander S. Pym | Zendy; Martin P. Grobusch | Zendy; R. F. Patientia | Zendy; Roxana Rustomjee | Zendy; Liesl PageShipp | Zendy; Christoffel Pistorius | Zendy; René Krause | Zendy; Mampedi Bogoshi | Zendy; Gavin Churchyard | Zendy; Amour Venter | Zendy; Jenny Allen | Zendy; Juan Carlos Palomino | Zendy; Tine De Marez | Zendy; Rolf P. G. van Heeswijk | Zendy; Nacer Lounis | Zendy; Paul Meyvisch | Zendy; Johan Verbeeck | Zendy; Wim Parys | Zendy; K. De Beule | Zendy; Koen Andries | Zendy; David F. Mc Neeley | Zendy

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The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

Author(s) -

Andreas H. Diacon,

Alexander S. Pym,

Martin P. Grobusch,

R. F. Patientia,

Roxana Rustomjee,

Liesl PageShipp,

Christoffel Pistorius,

René Krause,

Mampedi Bogoshi,

Gavin Churchyard,

Amour Venter,

Jenny Allen,

Juan Carlos Palomino,

Tine De Marez,

Rolf P. G. van Heeswijk,

Nacer Lounis,

Paul Meyvisch,

Johan Verbeeck,

Wim Parys,

K. De Beule,

Koen Andries,

David F. Mc Neeley

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0808427

Subject(s) - medicine , culture conversion , sputum , tuberculosis , placebo , sputum culture , gastroenterology , multiple drug resistance , mycobacterium tuberculosis , regimen , drug resistance , hazard ratio , confidence interval , surgery , microbiology and biotechnology , pathology , biology , alternative medicine

The diarylquinoline TMC207 offers a new mechanism of antituberculosis action by inhibiting mycobacterial ATP synthase. TMC207 potently inhibits drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro and shows bactericidal activity in patients who have drug-susceptible pulmonary tuberculosis.

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