Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia | Zendy

Charles G. Mullighan | Zendy; Xiaoping Su | Zendy; Jinghui Zhang | Zendy; Ina Radtke | Zendy; Letha A. Phillips | Zendy; Christopher B. Miller | Zendy; Jing Ma | Zendy; Wei Liu | Zendy; Cheng Cheng | Zendy; Brenda A. Schulman | Zendy; Richard C. Harvey | Zendy; IMing Chen | Zendy; Robert Clifford | Zendy; William L. Carroll | Zendy; Gregory H. Reaman | Zendy; W. Paul Bowman | Zendy; Meenakshi Devidas | Zendy; Daniela S. Gerhard | Zendy; Wenjian Yang | Zendy; Mary V. Relling | Zendy; Sheila Shurtleff | Zendy; Dario Campana | Zendy; Michael J. Borowitz | Zendy; ChingHon Pui | Zendy; Malcolm A. Smith | Zendy; Stephen P. Hunger | Zendy; Cheryl L. Willman | Zendy; James R. Downing | Zendy

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Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

Author(s) -

Charles G. Mullighan,

Xiaoping Su,

Jinghui Zhang,

Ina Radtke,

Letha A. Phillips,

Christopher B. Miller,

Jing Ma,

Wei Liu,

Cheng Cheng,

Brenda A. Schulman,

Richard C. Harvey,

IMing Chen,

Robert Clifford,

William L. Carroll,

Gregory H. Reaman,

W. Paul Bowman,

Meenakshi Devidas,

Daniela S. Gerhard,

Wenjian Yang,

Mary V. Relling,

Sheila Shurtleff,

Dario Campana,

Michael J. Borowitz,

ChingHon Pui,

Malcolm A. Smith,

Stephen P. Hunger,

Cheryl L. Willman,

James R. Downing

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0808253

Subject(s) - medicine , oncology , cohort , gene expression profiling , acute lymphocytic leukemia , gene signature , leukemia , gene , immunology , bioinformatics , genetics , gene expression , biology , lymphoblastic leukemia

Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined.

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