Fatal Case of Deer Tick Virus Encephalitis | Zendy

Norma P. Tavakoli | Zendy; Libin Chen | Zendy; Michelle Dupuis | Zendy; Rene Hull | Zendy; Gregory D. Ebel | Zendy; Emily J. Gilmore | Zendy; Phyllis L. Faust | Zendy

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Fatal Case of Deer Tick Virus Encephalitis

Author(s) -

Norma P. Tavakoli,

Libin Chen,

Michelle Dupuis,

Rene Hull,

Gregory D. Ebel,

Emily J. Gilmore,

Phyllis L. Faust

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0806326

Subject(s) - virology , encephalitis , tick , virus , tick borne encephalitis virus , veterinary virology , biology

Deer tick virus is related to Powassan virus, a tickborne encephalitis virus. A 62-year-old man presented with a meningoencephalitis syndrome and eventually died. Analyses of tissue samples obtained during surgery and at autopsy revealed a widespread necrotizing meningoencephalitis. Nucleic acid was extracted from formalin-fixed tissue, and the presence of deer tick virus was verified on a flavivirus-specific polymerase-chain-reaction (PCR) assay, followed by sequence confirmation. Immunohistochemical analysis with antisera specific for deer tick virus identified numerous immunoreactive neurons, with prominent involvement of large neurons in the brain stem, cerebellum, basal ganglia, thalamus, and spinal cord. This case demonstrates that deer tick virus can be a cause of fatal encephalitis.

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