B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia | Zendy

Ola Landgren | Zendy; Maher Albitar | Zendy; Wanlong Ma | Zendy; Fatima Abbasi | Zendy; Richard B. Hayes | Zendy; Paolo Ghia | Zendy; Gerald E. Marti | Zendy; Neil E. Caporaso | Zendy

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B-Cell Clones as Early Markers for Chronic Lymphocytic Leukemia

Author(s) -

Ola Landgren,

Maher Albitar,

Wanlong Ma,

Fatima Abbasi,

Richard B. Hayes,

Paolo Ghia,

Gerald E. Marti,

Neil E. Caporaso

Publication year - 2009

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0806122

Subject(s) - ighv@ , chronic lymphocytic leukemia , clone (java method) , medicine , population , cd5 , immunology , antibody , lymphocytosis , leukemia , biology , gene , genetics , environmental health

Otherwise healthy persons with a small number of B-cell clones circulating in the peripheral blood have been designated as having monoclonal B-cell lymphocytosis (MBL). Hospital-based series indicate an excess risk of progression from MBL to chronic lymphocytic leukemia (CLL). In this prospective cohort study, we tested the hypothesis that CLL is always preceded by MBL.

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