Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System | Zendy

Takashi Kishimoto | Zendy; Karthik Viswanathan | Zendy; Tanmoy Ganguly | Zendy; Subbiah Elankumaran | Zendy; Sean G. Smith | Zendy; Kevin D. Pelzer | Zendy; Jonathan C. Lansing | Zendy; Nammalwar Sriranganathan | Zendy; Ganlin Zhao | Zendy; Zoya Galcheva-Gargova | Zendy; Ali AlHakim | Zendy; Gregory Scott Bailey | Zendy; Blair A. Fraser | Zendy; Sucharita Roy | Zendy; Thomas Rogers-Cotrone | Zendy; Lucinda F. Buhse | Zendy; Mark T. Whary | Zendy; James G. Fox | Zendy; Moheb Nasr | Zendy; Gerald J. Dal Pan | Zendy; Zachary Shriver | Zendy; Róbert Langer | Zendy; Ganesh Venkataraman | Zendy; K. Frank Austen | Zendy; Janet Woodcock | Zendy; Ram Sasisekharan | Zendy

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Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Author(s) -

Takashi Kishimoto,

Karthik Viswanathan,

Tanmoy Ganguly,

Subbiah Elankumaran,

Sean G. Smith,

Kevin D. Pelzer,

Jonathan C. Lansing,

Nammalwar Sriranganathan,

Ganlin Zhao,

Zoya Galcheva-Gargova,

Ali AlHakim,

Gregory Scott Bailey,

Blair A. Fraser,

Sucharita Roy,

Thomas Rogers-Cotrone,

Lucinda F. Buhse,

Mark T. Whary,

James G. Fox,

Moheb Nasr,

Gerald J. Dal Pan,

Zachary Shriver,

Róbert Langer,

Ganesh Venkataraman,

K. Frank Austen,

Janet Woodcock,

Ram Sasisekharan

Publication year - 2008

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0803200

Subject(s) - heparin , medicine , complement system , kallikrein , chondroitin sulfate , pharmacology , mediator , anaphylatoxin , adverse effect , factor xii , immunology , glycosaminoglycan , biochemistry , coagulation , chemistry , antibody , enzyme , anatomy

There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin administration in the United States and Germany.

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