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Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Author(s) -
The ONTARGET Investigators
Publication year - 2008
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa0801317
Subject(s) - ramipril , telmisartan , medicine , diabetes mellitus , ace inhibitor , angiotensin receptor blockers , heart failure , cardiology , angiotensin converting enzyme , vascular disease , pharmacology , endocrinology , blood pressure
In patients who have vascular disease or high-risk diabetes without heart failure, angiotensin-converting-enzyme (ACE) inhibitors reduce mortality and morbidity from cardiovascular causes, but the role of angiotensin-receptor blockers (ARBs) in such patients is unknown. We compared the ACE inhibitor ramipril, the ARB telmisartan, and the combination of the two drugs in patients with vascular disease or high-risk diabetes.

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