Effect of Variation inCHI3L1on Serum YKL-40 Level, Risk of Asthma, and Lung Function | Zendy

Carole Ober | Zendy; Zheng Tan | Zendy; Ying Sun | Zendy; Jennifer D. Possick | Zendy; Lin Pan | Zendy; Raluca Nicolae | Zendy; Sadie Radford | Zendy; Rodney Parry | Zendy; Andrea Heinzmann | Zendy; Klaus A. Deichmann | Zendy; Lucille A. Lester | Zendy; James E. Gern | Zendy; Robert F. Lemanske | Zendy; Dan L. Nicolae | Zendy; Jack A. Elias | Zendy; Geoffrey Chupp | Zendy

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Effect of Variation inCHI3L1on Serum YKL-40 Level, Risk of Asthma, and Lung Function

Author(s) -

Carole Ober,

Zheng Tan,

Ying Sun,

Jennifer D. Possick,

Lin Pan,

Raluca Nicolae,

Sadie Radford,

Rodney Parry,

Andrea Heinzmann,

Klaus A. Deichmann,

Lucille A. Lester,

James E. Gern,

Robert F. Lemanske,

Dan L. Nicolae,

Jack A. Elias,

Geoffrey Chupp

Publication year - 2008

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0708801

Subject(s) - asthma , medicine , single nucleotide polymorphism , snp , population , cohort , immunology , bronchial hyperresponsiveness , lung , respiratory disease , genotype , biology , gene , genetics , environmental health

The chitinase-like protein YKL-40 is involved in inflammation and tissue remodeling. We recently showed that serum YKL-40 levels were elevated in patients with asthma and were correlated with severity, thickening of the subepithelial basement membrane, and pulmonary function. We hypothesized that single-nucleotide polymorphisms (SNPs) that affect YKL-40 levels also influence asthma status and lung function.

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