Mechanical Ventilation Guided by Esophageal Pressure in Acute Lung Injury | Zendy

Daniel Talmor | Zendy; Todd Sarge | Zendy; Atul Malhotra | Zendy; Carl R. O’Donnell | Zendy; R Ritz | Zendy; Alan Lisbon | Zendy; Victor Novack | Zendy; Stephen H. Loring | Zendy

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Mechanical Ventilation Guided by Esophageal Pressure in Acute Lung Injury

Author(s) -

Daniel Talmor,

Todd Sarge,

Atul Malhotra,

Carl R. O’Donnell,

R Ritz,

Alan Lisbon,

Victor Novack,

Stephen H. Loring

Publication year - 2008

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa0708638

Subject(s) - medicine , ards , transpulmonary pressure , mechanical ventilation , anesthesia , positive end expiratory pressure , fraction of inspired oxygen , pulmonary compliance , oxygenation , ventilation (architecture) , lung , lung volumes , engineering , mechanical engineering

Survival of patients with acute lung injury or the acute respiratory distress syndrome (ARDS) has been improved by ventilation with small tidal volumes and the use of positive end-expiratory pressure (PEEP); however, the optimal level of PEEP has been difficult to determine. In this pilot study, we estimated transpulmonary pressure with the use of esophageal balloon catheters. We reasoned that the use of pleural-pressure measurements, despite the technical limitations to the accuracy of such measurements, would enable us to find a PEEP value that could maintain oxygenation while preventing lung injury due to repeated alveolar collapse or overdistention.

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