Eprodisate for the Treatment of Renal Disease in AA Amyloidosis | Zendy

Laura M. Dember | Zendy; Philip N. Hawkins | Zendy; Bouke P. C. Hazenberg | Zendy; Peter D. Gorevic | Zendy; Giampaolo Merlini | Zendy; İrena Butrimienė | Zendy; Avi Livneh | Zendy; O. M. Lesnyak | Zendy; Xavier Puéchal | Zendy; Helen J. Lachmann | Zendy; Laura Obici | Zendy; Robert Balshaw | Zendy; Denis Garceau | Zendy; W. Hauck | Zendy; Martha Skinner | Zendy

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Eprodisate for the Treatment of Renal Disease in AA Amyloidosis

Author(s) -

Laura M. Dember,

Philip N. Hawkins,

Bouke P. C. Hazenberg,

Peter D. Gorevic,

Giampaolo Merlini,

İrena Butrimienė,

Avi Livneh,

O. M. Lesnyak,

Xavier Puéchal,

Helen J. Lachmann,

Laura Obici,

Robert Balshaw,

Denis Garceau,

W. Hauck,

Martha Skinner

Publication year - 2007

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa065644

Subject(s) - amyloidosis , amyloid (mycology) , fibril , aa amyloidosis , medicine , amyloid fibril , glycosaminoglycan , serum amyloid a , serum amyloid a protein , pathology , biochemistry , disease , chemistry , immunology , amyloid β , inflammation , anatomy , familial mediterranean fever

Amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) are deposited in tissues as amyloid fibrils. Amyloid deposition in the kidney causes progressive deterioration in renal function. Eprodisate is a member of a new class of compounds designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues.

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