Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition | Zendy

Raphaela GoldbachMansky | Zendy; Natalie Dailey Garnes | Zendy; Scott Canna | Zendy; A Gelabert | Zendy; Janet H. Jones | Zendy; Benjamin I. Rubin | Zendy; H. Jeffrey Kim | Zendy; Carmen C. Brewer | Zendy; Christopher Zalewski | Zendy; Edythe Wiggs | Zendy; Suvimol Hill | Zendy; Maria L. Turner | Zendy; Barbara I. Karp | Zendy; Ivona Aksentijevich | Zendy; Frank Pucino | Zendy; Scott Penzak | Zendy; Margje H. Haverkamp | Zendy; Leonard D. Stein | Zendy; Barbara S. Adams | Zendy; Terry L. Moore | Zendy; Robert C. Fuhlbrigge | Zendy; Bracha Shaham | Zendy; James N. Jarvis | Zendy; Kathleen M. O’Neil | Zendy; Richard K. Vehe | Zendy; Laurie Beitz | Zendy; Gregory C. Gardner | Zendy; William P. Hannan | Zendy; Robert W. Warren | Zendy; William Horn | Zendy; Joe L. Cole | Zendy; Scott M. Paul | Zendy; Philip N. Hawkins | Zendy; Tuyet Pham | Zendy; Christopher S. Snyder | Zendy; Robert Wesley | Zendy; Steven C. Hoffmann | Zendy; Steven M. Holland | Zendy; John A. Butman | Zendy; Daniel L. Kastner | Zendy

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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

Author(s) -

Raphaela GoldbachMansky,

Natalie Dailey Garnes,

Scott Canna,

A Gelabert,

Janet H. Jones,

Benjamin I. Rubin,

H. Jeffrey Kim,

Carmen C. Brewer,

Christopher Zalewski,

Edythe Wiggs,

Suvimol Hill,

Maria L. Turner,

Barbara I. Karp,

Ivona Aksentijevich,

Frank Pucino,

Scott Penzak,

Margje H. Haverkamp,

Leonard D. Stein,

Barbara S. Adams,

Terry L. Moore,

Robert C. Fuhlbrigge,

Bracha Shaham,

James N. Jarvis,

Kathleen M. O’Neil,

Richard K. Vehe,

Laurie Beitz,

Gregory C. Gardner,

William P. Hannan,

Robert W. Warren,

William Horn,

Joe L. Cole,

Scott M. Paul,

Philip N. Hawkins,

Tuyet Pham,

Christopher S. Snyder,

Robert Wesley,

Steven C. Hoffmann,

Steven M. Holland,

John A. Butman,

Daniel L. Kastner

Publication year - 2006

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa055137

Subject(s) - anakinra , medicine , erythrocyte sedimentation rate , rash , gastroenterology , c reactive protein , serum amyloid a , immunology , inflammation , disease

Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a protein that regulates inflammation.

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