Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis | Zendy

Silvia Svegliati | Zendy; Mariarosaria Santillo | Zendy; Federica Bevilacqua | Zendy; Michele Maria Luchetti | Zendy; Tatiana Spadoni | Zendy; Matteo Mancini | Zendy; Paolo Fraticelli | Zendy; Paola Sambo | Zendy; Ada Funaro | Zendy; Andrius Kazlauskas | Zendy; Enrico V. Avvedimento | Zendy; Armando Gabrielli | Zendy

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Stimulatory Autoantibodies to the PDGF Receptor in Systemic Sclerosis

Author(s) -

Silvia Svegliati,

Mariarosaria Santillo,

Federica Bevilacqua,

Michele Maria Luchetti,

Tatiana Spadoni,

Matteo Mancini,

Paolo Fraticelli,

Paola Sambo,

Ada Funaro,

Andrius Kazlauskas,

Enrico V. Avvedimento,

Armando Gabrielli

Publication year - 2006

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa052955

Subject(s) - autoantibody , medicine , scleroderma (fungus) , platelet derived growth factor receptor , fibrosis , fibroblast , platelet derived growth factor , connective tissue disease , oxidative stress , immunology , receptor , growth factor , antibody , pathology , autoimmune disease , endocrinology , biology , cell culture , inoculation , genetics

Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulates the production of reactive oxygen species (ROS) and since IgG from patients with scleroderma reacts with human fibroblasts, we tested the hypothesis that patients with scleroderma have serum autoantibodies that stimulate the PDGF receptor (PDGFR), activating collagen-gene expression.

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