Influence of Donor C3 Allotype on Late Renal-Transplantation Outcome | Zendy

Katherine Brown | Zendy; E. Kondeatis | Zendy; R. W. Vaughan | Zendy; Sui Phin Kon | Zendy; Chris Farmer | Zendy; John Taylor | Zendy; Xiang He | Zendy; A. E. Johnston | Zendy; Catherine Horsfield | Zendy; B.J.C. Janssen | Zendy; Piet Gros | Zendy; Wuding Zhou | Zendy; Steven H. Sacks | Zendy; Neil Sheerin | Zendy

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Influence of Donor C3 Allotype on Late Renal-Transplantation Outcome

Author(s) -

Katherine Brown,

E. Kondeatis,

R. W. Vaughan,

Sui Phin Kon,

Chris Farmer,

John Taylor,

Xiang He,

A. E. Johnston,

Catherine Horsfield,

B.J.C. Janssen,

Piet Gros,

Wuding Zhou,

Steven H. Sacks,

Neil Sheerin

Publication year - 2006

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa052825

Subject(s) - allotype , medicine , allele , hazard ratio , kidney transplantation , kidney , transplantation , renal function , confidence interval , immunology , gastroenterology , antibody , genetics , biology , gene

The complement system has a critical role in both the innate and the adaptive immune responses. In humans, C3 exists as two main allotypes, F (fast) and S (slow), which are known to affect the incidence of inflammatory disease. We conducted a study to address the influence of these alleles on late renal-graft outcome.

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