Severe Expressive-Language Delay Related to Duplication of the Williams–Beuren Locus | Zendy

Martin J. Somerville | Zendy; Carolyn Β. Mervis | Zendy; Edwin J. Young | Zendy; EulJu Seo | Zendy; Miguel Del Campo | Zendy; Stephen Bamforth | Zendy; Ella Peregrine | Zendy; Wayne Loo | Zendy; Margaret Lilley | Zendy; Luis A. PérezJurado | Zendy; Colleen A. Morris | Zendy; Stephen W. Scherer | Zendy; Lucy R. Osborne | Zendy

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Severe Expressive-Language Delay Related to Duplication of the Williams–Beuren Locus

Author(s) -

Martin J. Somerville,

Carolyn Β. Mervis,

Edwin J. Young,

EulJu Seo,

Miguel Del Campo,

Stephen Bamforth,

Ella Peregrine,

Wayne Loo,

Margaret Lilley,

Luis A. PérezJurado,

Colleen A. Morris,

Stephen W. Scherer,

Lucy R. Osborne

Publication year - 2005

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa051962

Subject(s) - locus (genetics) , gene duplication , phenotype , medicine , cognition , williams syndrome , gene , genetics , neuroscience , biology

The Williams-Beuren syndrome (WBS) locus, at 7q11.23, is prone to recurrent chromosomal rearrangements, including the microdeletion that causes WBS, a multisystem condition with characteristic cardiovascular, cognitive, and behavioral features. It is hypothesized that reciprocal duplications of the WBS interval should also occur, and here we present such a case description. The most striking phenotype was a severe delay in expressive speech, in contrast to the normal articulation and fluent expressive language observed in persons with WBS. Our results suggest that specific genes at 7q11.23 are exquisitely sensitive to dosage alterations that can influence human language and visuospatial capabilities.

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