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Peginterferon Alfa-2a, Lamivudine, and the Combination for HBeAg-Positive Chronic Hepatitis B
Author(s) -
George Lau,
Teerha Piratvisuth,
Kang Luo,
Patrick Marcellin,
Satawat Thongsawat,
Graham Cooksley,
Edward Gane,
Michael Fried,
Wan Cheng Chow,
Seung Woon Paik,
Wen Yu Chang,
Thomas Berg,
Robert Flisiak,
Philip McCloud,
N. Pluck
Publication year - 2005
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa043470
Subject(s) - lamivudine , medicine , gastroenterology , hbeag , hbsag , peginterferon alfa 2a , seroconversion , pegylated interferon , adverse effect , alpha interferon , hepatitis b , interferon alfa , hepatitis b virus , interferon , virology , chronic hepatitis , virus , ribavirin
Current treatments for chronic hepatitis B are suboptimal. In the search for improved therapies, we compared the efficacy and safety of pegylated interferon alfa plus lamivudine, pegylated interferon alfa without lamivudine, and lamivudine alone for the treatment of hepatitis B e antigen (HBeAg)-positive chronic hepatitis B.

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