Effectiveness of Mass Oral Cholera Vaccination in Beira, Mozambique
Author(s) -
Marcelino Lucas,
Jacqueline Deen,
Lorenz von Seidlein,
Xuan-Yi Wang,
Julia S. Ampuero,
Mahesh Puri,
Mohammad Ali,
M. Ansaruzzaman,
Juvenaldo Amos,
Arminda Macuamule,
Philippe Cavailler,
Philippe J. Guérin,
Claude Mahoudeau,
Pierre Kahozi-Sangwa,
ClaireLise Chaignat,
Avertino Barreto,
Francisco Songane,
John D. Clemens
Publication year - 2005
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa043323
Subject(s) - cholera vaccine , medicine , cholera , vaccination , diarrhea , population , immunization , regimen , vaccine efficacy , immunology , pediatrics , virology , environmental health , vibrio cholerae , antibody , biology , bacteria , genetics
New-generation, orally administered cholera vaccines offer the promise of improved control of cholera in sub-Saharan Africa. However, the high prevalence of human immunodeficiency virus (HIV) infection in many cholera-affected African populations has raised doubts about the level of protection possible with vaccination. We evaluated a mass immunization program with recombinant cholera-toxin B subunit, killed whole-cell (rBS-WC) oral cholera vaccine in Beira, Mozambique, a city where the seroprevalence of HIV is 20 to 30 percent.
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