U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection | Zendy

Nick Maskell | Zendy; Christopher W.H. Davies | Zendy; Andrew Nunn | Zendy; Emma Hedley | Zendy; Fergus Gleeson | Zendy; Robert F. Miller | Zendy; Rhian Gabe | Zendy; Glyn L. Rees | Zendy; Tim Peto | Zendy; Mark Woodhead | Zendy; D J Lane | Zendy; Janet Darbyshire | Zendy; Robert J.O. Davies | Zendy

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U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection

Author(s) -

Nick Maskell,

Christopher W.H. Davies,

Andrew Nunn,

Emma Hedley,

Fergus Gleeson,

Robert F. Miller,

Rhian Gabe,

Glyn L. Rees,

Tim Peto,

Mark Woodhead,

D J Lane,

Janet Darbyshire,

Robert J.O. Davies

Publication year - 2005

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa042473

Subject(s) - medicine , streptokinase , clinical trial , pleural fluid , fibrinolytic therapy , surgery , intensive care medicine , anesthesia , pleural effusion , myocardial infarction

Intrapleural fibrinolytic agents are used in the drainage of infected pleural-fluid collections. This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase.

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