Clopidogrel versus Aspirin and Esomeprazole to Prevent Recurrent Ulcer Bleeding
Author(s) -
Francis K.L. Chan,
Jessica Ching,
Lawrence C.T. Hung,
Vincent WaiSun Wong,
Vincent K S Leung,
Nelson N.S. Kung,
Aric J. Hui,
Justin C.Y. Wu,
Wai K. Leung,
Vivian Lee,
Kenneth K.C. Lee,
Yuk T. Lee,
James Y. Lau,
KaFai To,
Henry LikYuen Chan,
S. C. S. Chung,
Joseph J.�Y. Sung
Publication year - 2005
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa042087
Subject(s) - esomeprazole , medicine , aspirin , clopidogrel , gastroenterology , proton pump inhibitor , confidence interval , placebo , randomized controlled trial , surgery , alternative medicine , pathology
Concurrent therapy with a proton-pump inhibitor is a standard treatment for patients receiving aspirin who are at risk for ulcer. Current U.S. guidelines also recommend clopidrogel for patients who have major gastrointestinal intolerance of aspirin. We compared clopidogrel with aspirin plus esomeprazole for the prevention of recurrent bleeding from ulcers in high-risk patients.
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