Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism | Zendy

Erik K. Alexander | Zendy; Ellen Marqusee | Zendy; Jennifer L. Lawrence | Zendy; Petr Jarolı́m | Zendy; G. Fischer | Zendy; P. Reed Larsen | Zendy

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Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism

Author(s) -

Erik K. Alexander,

Ellen Marqusee,

Jennifer L. Lawrence,

Petr Jarolı́m,

G. Fischer,

P. Reed Larsen

Publication year - 2004

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa040079

Subject(s) - levothyroxine , medicine , pregnancy , prospective cohort study , obstetrics , fetus , thyroid , hormone , pediatrics , endocrinology , genetics , biology

Hypothyroidism during pregnancy has been associated with impaired cognitive development and increased fetal mortality. During pregnancy, maternal thyroid hormone requirements increase. Although it is known that women with hypothyroidism should increase their levothyroxine dose during pregnancy, biochemical hypothyroidism occurs in many. In this prospective study we attempted to identify precisely the timing and amount of levothyroxine adjustment required during pregnancy.

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