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Dose-Related Effects of Smallpox Vaccine
Author(s) -
Sharon E. Frey,
Frances K. Newman,
John Cruz,
W. Brian Shelton,
Janice Tennant,
Tamara Polach,
Alan L. Rothman,
Jeffrey S. Kennedy,
Mark Wolff,
Robert B. Belshe,
Francis A. Ennis
Publication year - 2002
Publication title -
new england journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 19.889
H-Index - 1030
eISSN - 1533-4406
pISSN - 0028-4793
DOI - 10.1056/nejmoa013431
Subject(s) - vaccinia , medicine , vaccination , liter , virus , virology , smallpox vaccine , titer , serial dilution , immunology , antibody , orthopoxvirus , poxviridae , cytotoxic t cell , biology , in vitro , pathology , biochemistry , gene , recombinant dna , alternative medicine
We conducted a double-blind, randomized trial of three dilutions of vaccinia virus vaccine in previously unimmunized adults in order to assess the clinical success rates, humoral responses, and virus-specific activity of cytotoxic T cells and interferon-gamma-producing T cells.

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