Salmeterol for the Prevention of High-Altitude Pulmonary Edema | Zendy

Cláudio Sartori | Zendy; Yves Allemann | Zendy; Hervé Duplain | Zendy; Mattia Lepori | Zendy; Marc Egli | Zendy; Ernst Lipp | Zendy; Damian Hutter | Zendy; Pierre Turini | Zendy; Olivier Hügli | Zendy; Stéphane Cook | Zendy; Pascal Nicod | Zendy; Urs Scherrer | Zendy

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Salmeterol for the Prevention of High-Altitude Pulmonary Edema

Author(s) -

Cláudio Sartori,

Yves Allemann,

Hervé Duplain,

Mattia Lepori,

Marc Egli,

Ernst Lipp,

Damian Hutter,

Pierre Turini,

Olivier Hügli,

Stéphane Cook,

Pascal Nicod,

Urs Scherrer

Publication year - 2002

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa013183

Subject(s) - medicine , pulmonary edema , edema , high altitude pulmonary edema , inhalation , anesthesia , salmeterol , lung , effects of high altitude on humans , placebo , pathology , anatomy , alternative medicine

Pulmonary edema results from a persistent imbalance between forces that drive water into the air space and the physiologic mechanisms that remove it. Among the latter, the absorption of liquid driven by active alveolar transepithelial sodium transport has an important role; a defect of this mechanism may predispose patients to pulmonary edema. Beta-adrenergic agonists up-regulate the clearance of alveolar fluid and attenuate pulmonary edema in animal models.

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