Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | Zendy

William C. Knowler | Zendy; Elizabeth BarrettConnor | Zendy; Sarah Fowler | Zendy; Richard F. Hamman | Zendy; John M. Lachin | Zendy; Elizabeth A. Walker | Zendy; David M. Nathan | Zendy

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

Author(s) -

William C. Knowler,

Elizabeth BarrettConnor,

Sarah Fowler,

Richard F. Hamman,

John M. Lachin,

Elizabeth A. Walker,

David M. Nathan

Publication year - 2002

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa012512

Subject(s) - metformin , medicine , overweight , type 2 diabetes , confidence interval , diabetes mellitus , placebo , body mass index , incidence (geometry) , weight loss , obesity , endocrinology , physics , alternative medicine , optics , pathology

Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a sedentary lifestyle--are potentially reversible. We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes.

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