Primary Chemoprevention of Familial Adenomatous Polyposis with Sulindac | Zendy

Francis M. Giardiello | Zendy; Vincent W. Yang | Zendy; Linda M. Hylind | Zendy; Anne J. Krush | Zendy; Gloria M. Petersen | Zendy; Jill D. Trimbath | Zendy; Steven Piantadosi | Zendy; Elizabeth Garrett | Zendy; Deborah E. Geiman | Zendy; Walter C. Hubbard | Zendy; G.J.A. Offerhaus | Zendy; Stanley R. Hamilton | Zendy

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Primary Chemoprevention of Familial Adenomatous Polyposis with Sulindac

Author(s) -

Francis M. Giardiello,

Vincent W. Yang,

Linda M. Hylind,

Anne J. Krush,

Gloria M. Petersen,

Jill D. Trimbath,

Steven Piantadosi,

Elizabeth Garrett,

Deborah E. Geiman,

Walter C. Hubbard,

G.J.A. Offerhaus,

Stanley R. Hamilton

Publication year - 2002

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa012015

Subject(s) - sulindac , familial adenomatous polyposis , adenomatous polyposis coli , colorectal cancer , medicine , nonsteroidal , gastroenterology , chemoprophylaxis , cancer research , oncology , cancer

Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown.

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