Deep-Brain Stimulation of the Subthalamic Nucleus or the Pars Interna of the Globus Pallidus in Parkinson's Disease | Zendy

José Á. Obeso | Zendy; C. Warren Olanow | Zendy; María RodríguezOroz | Zendy; Paul Krack | Zendy; Ritesh Kumar | Zendy; Anthony E. Lang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Deep-Brain Stimulation of the Subthalamic Nucleus or the Pars Interna of the Globus Pallidus in Parkinson's Disease

Author(s) -

José Á. Obeso,

C. Warren Olanow,

María RodríguezOroz,

Paul Krack,

Ritesh Kumar,

Anthony E. Lang

Publication year - 2001

Publication title -

new england journal of medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 19.889

H-Index - 1030

eISSN - 1533-4406

pISSN - 0028-4793

DOI - 10.1056/nejmoa000827

Subject(s) - subthalamic nucleus , deep brain stimulation , globus pallidus , medicine , parkinson's disease , stimulation , parkinsonism , basal ganglia , anesthesia , disease , central nervous system

Increased neuronal activity in the subthalamic nucleus and the pars interna of the globus pallidus is thought to account for motor dysfunction in patients with Parkinson's disease. Although creating lesions in these structures improves motor function in monkeys with induced parkinsonism and patients with Parkinson's disease, such lesions are associated with neurologic deficits, particularly when they are created bilaterally. Deep-brain stimulation simulates the effects of a lesion without destroying brain tissue.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research