Open AccessSynthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes
Author(s) -
Olivier Provot,
Mouâd Alami,
Gaëlle Le Bras,
Abdallah Hamzé,
Samir Messaoudi,
PierreBenoit Le Calvez,
JeanDaniel Brion
Publication year - 2008
Publication title -
synthesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 140
eISSN - 1437-210X
pISSN - 0039-7881
DOI - 10.1055/s-2008-1072575
Subject(s) - isocoumarins , isocoumarin , annulation , catalysis , p toluenesulfonic acid , microwave irradiation , chemistry , aryl , organic chemistry , combinatorial chemistry , alkyl
p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of a range of 3-aryl-substituted isocoumarins in good yields.
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