An Efficient Strategy for the Synthesis of α,α′-cis and trans-Disubstituted Medium Ring Ethers | Zendy

Michael T. Crimmins | Zendy; Kyle A. Emmitte | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

An Efficient Strategy for the Synthesis of α,α′-cis and trans-Disubstituted Medium Ring Ethers

Author(s) -

Michael T. Crimmins,

Kyle A. Emmitte

Publication year - 2000

Publication title -

synthesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.885

H-Index - 140

eISSN - 1437-210X

pISSN - 0039-7881

DOI - 10.1055/s-2000-6268

Subject(s) - chemistry , alkylation , ring closing metathesis , ring (chemistry) , alkoxy group , closure (psychology) , metathesis , enantioselective synthesis , ruthenium , catalysis , stereochemistry , combinatorial chemistry , organic chemistry , polymerization , polymer , alkyl , economics , market economy

An asymmetric alkylation-ring-closing metathesis strat- egy was developed for the construction of a,a'-disubstituted medi- um ring ethers. The approach features an asymmetric alkylation of highly functionalized a-alkoxy acyl oxazolidinones followed by ring closure effected by Grubbs ' ruthenium catalyst. The relation- ship between diene conformation and the rate of ring-closure was examined.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research