Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease | Zendy

Jérémy Ortillon | Zendy; Nathalie Hézard | Zendy; Karim Belmokhtar | Zendy; Charlotte Kawecki | Zendy; Christine Terryn | Zendy; G. Fritz | Zendy; Alexandre Kauskot | Zendy; Ann Marie Schmidt | Zendy; Philippe Rieu | Zendy; Philippe Nguyên | Zendy; Pascal Maurice | Zendy; Fatouma Touré | Zendy

Open Access

Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease

Author(s) -

Jérémy Ortillon,

Nathalie Hézard,

Karim Belmokhtar,

Charlotte Kawecki,

Christine Terryn,

G. Fritz,

Alexandre Kauskot,

Ann Marie Schmidt,

Philippe Rieu,

Philippe Nguyên,

Pascal Maurice,

Fatouma Touré

Publication year - 2020

Publication title -

thrombosis and haemostasis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.97

H-Index - 188

eISSN - 2567-689X

pISSN - 0340-6245

DOI - 10.1055/s-0040-1714101

Subject(s) - platelet , medicine , rage (emotion) , endocrinology , kidney disease , apolipoprotein e , glycation , platelet activation , thrombosis , renal function , hyperactivation , diabetes mellitus , biology , disease , neuroscience

Chronic kidney disease (CKD) is associated with a high cardiovascular mortality due to increased rates of vascular lesions and thrombotic events, as well as serum accumulation of uremic toxins. A subgroup of these toxins (advanced glycation end products [AGEs] and S100 proteins) can interact with the receptor for AGEs (RAGE). In this study, we analyzed the impact of CKD on platelet function and arterial thrombosis, and the potential role of RAGE in this process.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research