Open AccessStereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome
Author(s) -
Ingrid F. Metzger,
Anna E. Thomas,
Cindy A. Evrard,
David R. Jones,
Andrea R. Masters,
David M. Haas,
Laura S. Haneline,
Sara K. Quinney
Publication year - 2020
Publication title -
american journal of perinatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 67
eISSN - 1098-8785
pISSN - 0735-1631
DOI - 10.1055/s-0040-1701505
Subject(s) - methadone , medicine , pregnancy , cord blood , abstinence , anesthesia , morphine , opioid use disorder , obstetrics , opioid , pediatrics , psychiatry , genetics , biology , receptor
This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS). The use of dried blood spots (DBS) as an alternative for plasma in assessing methadone and EDDP was also assessed.