Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum | Zendy

James Turvill | Zendy; Patrick M. Connor | Zendy; Michael J.G. Farthing | Zendy

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Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum

Author(s) -

James Turvill,

Patrick M. Connor,

Michael J.G. Farthing

Publication year - 2000

Publication title -

gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.828

H-Index - 402

eISSN - 1528-0012

pISSN - 0016-5085

DOI - 10.1053/gast.2000.18147

Subject(s) - cholera toxin , substance p , neurokinin a , enterotoxigenic escherichia coli , medicine , receptor , endocrinology , chemistry , neurokinin b , toxin , pharmacology , capsaicin , biology , enterotoxin , neuropeptide , microbiology and biotechnology , biochemistry , escherichia coli , gene

Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neurokinin receptor antagonists on cholera toxin-, Escherichia coli heat-labile enterotoxin (LT)-, and heat-stable enterotoxin (STa)-induced water secretion in an in vivo rat jejunal perfusion model.

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