Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation | Zendy

Michele Brignole | Zendy; Lorella Gianfranchi | Zendy; C. Menozzi | Zendy; Paoló Alboni | Zendy; Giacomo Musso | Zendy; Maria Grazia Bongiorni | Zendy; Maurizio Gasparini | Zendy; Antonio Raviele | Zendy; G Lolli | Zendy; Nelly Paparella | Zendy; Simonetta Acquarone | Zendy

Open Access

Prospective, randomized study of atrioventricular ablation and mode-switching, dual chamber pacemaker implantation versus medical therapy in drug-resistant paroxysmal atrial fibrillation

Author(s) -

Michele Brignole,

Lorella Gianfranchi,

C. Menozzi,

Paoló Alboni,

Giacomo Musso,

Maria Grazia Bongiorni,

Maurizio Gasparini,

Antonio Raviele,

G Lolli,

Nelly Paparella,

Simonetta Acquarone

Publication year - 1999

Publication title -

ep europace

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.119

H-Index - 102

eISSN - 1532-2092

pISSN - 1099-5129

DOI - 10.1053/eupc.1998.0007

Subject(s) - medicine , paroxysmal atrial fibrillation , discontinuation , atrial fibrillation , ablation , cardiology , randomized controlled trial

We performed a prospective randomized 6-month evaluation of the clinical effects of atrioventricular junctional ablation together with placement of a DDDR mode-switching pacemaker vs pharmacological treatment in 43 patients with intolerable paroxysmal atrial fibrillation not controlled with antiarrhythmic drugs. Ablation and pacemaker treatment were highly effective and superior to drug therapy in controlling symptoms and improving quality of life. However, discontinuation of drug therapy exposed patients to further recurrences of paroxysmal atrial fibrillation and the risk of developing permanent atrial fibrillation.

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