Importance of sympathetic activation for the expression of Na+-Ca2+ exchanger in end-stage failing human myocardium | Zendy

Wolfgang Schillinger | Zendy

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Importance of sympathetic activation for the expression of Na+-Ca2+ exchanger in end-stage failing human myocardium

Author(s) -

Wolfgang Schillinger

Publication year - 2002

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.2001.3044

Subject(s) - medicine , sodium–hydrogen antiporter , endocrinology , sodium calcium exchanger , heart failure , norepinephrine , aldosterone , plasma renin activity , renin–angiotensin system , calcium , sodium , chemistry , dopamine , blood pressure , organic chemistry

In end-stage heart failure, an alteration in the expression of the Na+-Ca2+ exchanger has been reported. Regulation of its expression is largely unknown. We sought to find out whether Na+-Ca2+ exchanger in human heart failure is regulated by sympathetic activation. In addition, since Na+-Ca2+-exchange is electrogenic, we conjectured whether increased expression of Na+-Ca2+ exchanger is associated with an increased incidence of cardiac arrhythmias.

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