Peak oxygen uptake is not determined by cardiac noradrenaline spillover in heart failure | Zendy

Catherine F. Notarius | Zendy

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Peak oxygen uptake is not determined by cardiac noradrenaline spillover in heart failure

Author(s) -

Catherine F. Notarius

Publication year - 2002

Publication title -

european heart journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.336

H-Index - 293

eISSN - 1522-9645

pISSN - 0195-668X

DOI - 10.1053/euhj.2001.2942

Subject(s) - medicine , heart failure , cardiology , vo2 max , peripheral , cardiac output , skeletal muscle , oxygen , heart rate , endocrinology , blood pressure , chemistry , organic chemistry

We recently found that resting muscle sympathetic nerve activity is inversely related to peak oxygen uptake (VO(2) peak) in patients with heart failure, suggesting a peripheral neurogenic limit to exercise in heart failure. No such relationship was observed in healthy controls. To determine whether this observation is specific to sympathetic discharge to skeletal muscle, we tested the null hypothesis that VO(2) peak would not relate to resting cardiac noradrenaline spillover, which is also elevated in heart failure.

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